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Sleep Reform™ Serumfeaturing Repair Enhancing Matrix™ (REM)Step 2: Treat | RepairClinically proven ingredient optimizes skin's night repair cycle by:Dramatically reducing signs of aging while you sleep to reveal a youthful appearance Stimulating the proliferation of the cells responsible for collagen production by 78%Innovative approach unlocks skin's potential to repair and renew itself by enhancing its sleep cycle. Empowers skin to effectively fight the signs of aging so you awaken to a rested, more youthful appearance.Topical Melatonin promotes skin's "sleep cycle", to maximize ability to repair and regenerate itself Repair Enhancing Matrix™ (REM) improves collagen production potential by 62% while encouraging relaxation to soften the appearance of facial expression lines Oligopeptide-1 encourages plump, firm texture and increases proliferation of cells so mature skin looks and acts youngerAt Murad, Transforming Skincare™ describes more than our history of breakthrough research and pioneering innovations; it describes more than our legacy as the first doctor brand and the first brand offering advanced formulations of pharmaceutical grade ingredients. It describes the promise of performance that stands behind every product we offer.We can also make that promise of transformation because our products are based in The Science of Cellular Water™ - the world's most comprehensive approach to understanding health and aging."Beautiful skin is healthy skin. Healthy skin is beautiful." - Howard Murad, MDSetting the Gold Standard in Skincare Since 1989Dermatologist developed. Tested on people, not animals. Scientifically Proven.Made in the USA